Common IV Antibiotics for MRSA

Common IV Antibiotics for MRSA

1. Vancomycin
   Use: First-line for serious MRSA infections, including bacteremia and pneumonia.
   Details: Requires monitoring of drug levels (trough levels) due to potential nephrotoxicity.

2. Daptomycin
   Use: MRSA bacteremia, right-sided endocarditis, and skin infections.
   Details: Not effective for pneumonia (inactivated by lung surfactant). Muscle toxicity concern, Ck monitoring. 

3. Linezolid 
   Use: MRSA pneumonia, skin infections, and VRE.
   Details: IV and PO forms have equivalent efficacy. Risk of bone marrow suppression with long-term use. Drug interaction with SSRI, SNRI etc..

4. Ceftaroline
   Use: MRSA skin infections, pneumonia.
   Details: A fifth-generation cephalosporin with MRSA activity.

5. Telavancin / Dalbavancin / Oritavancin
   Use: MRSA skin infections and bloodstream infections.
   Details: Long-acting options (dalbavancin and oritavancin) allow for infrequent dosing.

6. Tigecycline/Eravacycline 
   Use: Complicated MRSA skin and intra-abdominal infections.
   Details: Generally used as a last resort due to side effect profile and lower efficacy in bacteremia.